The 42-man squad will meet for a three-day training camp from Monday, 18 May at England's Performance Centre at Pennyhill Park in London.
The inclusion of Janse van Rensburg comes after World Rugby confirmed with England that he will be eligible to represent the Red Rose from 8 July. England begin their Nations Championship campaign against the Springboks at Ellis Park on Saturday, 4 July, followed by matches against Fiji and Argentina.
Janse van Rensburg, a former Junior Springbok, ran out for the Sharks and Cheetahs in domestic rugby before signing with the Bristol Bears in 2023. The burly centre impressed and was named in the Premiership Rugby Team of the Season for the 2023/24.
The Pretoria-born star also ran out for the Barbarians against the All Blacks last November.
England squad
Forwards: Jamie Blamire, Ollie Chessum, Arthur Clark, Alex Coles, Chandler Cunningham-South, Tom Curry, Theo Dan, Alex Dombrandt, Ben Earl, Ellis Genge, Jamie George, Joe Heyes, Nick Isiekwe, Maro Itoje, Emmanuel Iyogun, George Martin, Beno Obano, Asher Opoku-Fordjour, Guy Pepper, Henry Pollock, Vilikesa Sela, Kepu Tuipulotu.
Backs: Seb Atkinson, Charlie Bracken, Noah Caluori, Fraser Dingwall, Immanuel Feyi-Waboso, George Ford, Tommy Freeman, George Furbank, Benhard Janse van Rensburg, Archie McParland, Alex Mitchell, Cadan Murley, Adam Radwan, Tom Roebuck, Henry Slade, Fin Smith, Marcus Smith, Ben Spencer, Freddie Steward, Jack van Poortvliet.
Cricket South Africa (CSA) has come under heavy criticism after tickets for the 2027 New Year's Test against England at Newlands sold out within minutes on Monday, with only a small percentage of seats made available to the general public.
Joao Pedro has thrown his support behind Harry Kane, saying the Bayern Munich forward has the quality to win the Ballon d'Or this year.
Seamer Ollie Robinson was a surprise inclusion in England's Test squad to face New Zealand, but director Rob Key is backing the big quick.
Arsenal have confirmed that defender Ben White will miss the remainder of the season after suffering a significant medial knee ligament injury.
