Sahibzada Farhan top-scored with 74 while fellow opener Saim Ayub struck 66 as Pakistan posted a total of 189-4 in their 20 overs after electing to bat first at the toss.
Spinner Roston Chase was the pick of the Windies bowlers with figures of 1-31 in his four overs while seamers Shamar Joseph and Jason Holder took a wicket apiece.
The Caribbean side were well-placed in the run-chased thanks to 60 from opener Alick Athanaze and Sherfane Rutherford, who struck a 35-ball 51.
Pakistan though fought back gallantly and chipped away in the wickets column with left-arm wrist-spinner Sufiyan Muqeem keeping it tight with 1-20 in his four overs.
West Indies were eventually restricted to a total of 176-6 to give Pakistan a 2-1 series win.
Justin Greaves says he will saviour a 'special day' after scoring a maiden double-century to help West Indies to an epic draw in the first Test against New Zealand in Christchurch.
New Zealand chased down a target of 162 to beat West Indies by four wickets to seal s clean sweep in the three-match ODI series at home.
The Proteas suffered a calamitous batting collapse as Pakistan claimed a seven-wicket win in the third and final ODI in Faisalabad on Saturday and with it a 2-1 series victory.
Quinton de Kock produced a batting masterclass as South Africa crushed Pakistan by eight wickets in the second ODI in Faisalabad, chasing down 270 with nearly 10 overs to spare to level the three-match series 1-1.
