Sahibzada Farhan top-scored with 74 while fellow opener Saim Ayub struck 66 as Pakistan posted a total of 189-4 in their 20 overs after electing to bat first at the toss.
Spinner Roston Chase was the pick of the Windies bowlers with figures of 1-31 in his four overs while seamers Shamar Joseph and Jason Holder took a wicket apiece.
The Caribbean side were well-placed in the run-chased thanks to 60 from opener Alick Athanaze and Sherfane Rutherford, who struck a 35-ball 51.
Pakistan though fought back gallantly and chipped away in the wickets column with left-arm wrist-spinner Sufiyan Muqeem keeping it tight with 1-20 in his four overs.
West Indies were eventually restricted to a total of 176-6 to give Pakistan a 2-1 series win.
Pakistan claimed a convincing 4-wicket victory over Australia in the 3rd ODI at Gaddafi Stadium, Lahore, on Thursday wrapping up the chase with 49 balls to spare.
Nathan Ellis took four wickets as Australia defended a target 232 to beat Pakistan by 41 runs in the second ODI in Lahore as the visitors levelled the three-match series with one game left to play.
Shimron Hetmyer has been "reintegrated" into West Indies' ODI squad ahead of the home series against Sri Lanka, starting on Wednesday, while fast bowler Alzarri Joseph also returns from injury.
Cricket West Indies unveiled an exciting schedule for the 2026 Men's International Home Series, setting the stage for an electrifying summer of cricket across the Caribbean.
