Left-arm fast bowler Afridi returned figures of 4-51 in eight overs while fellow seamer Naseem Shah took 3-55 as visitors restricted the Windies to a total of 280 all out in Trinidad.
Opener Evin Lewis top-scored for the hosts with 60 while captain Shai Hope contributed 55 before Roston Chase struck 53 but the Windies could not capitalise after being in a strong position of 105-2 in the 19th over.
Pakistan were then in a spot of bother as they slipped to 180-5 in the run-chase despite a fighting 53 from skipper Mohammad Rizwan.
Nawaz and Talat then combined for a unbroken 104-run and took the attack to the Windies bowlers as the stand came in just 70 balls.
Nawaz struck 63 not out from 54 balls while Talat was unbeaten on 41 off 37 deliveries as Pakistan took a 1-0 lead with two matches still to play in the series.
Australia Women star Ellyse Perry wrote another chapter in her storied career by almost single-handedly guiding her side to an 113-run win over Pakistan at the ICC Women's T20 World Cup.
The Proteas Women revived their ICC T20 World Cup campaign with a two-wicket victory over Pakistan in their Group A encounter at Edgbaston on Wednesday.
West Indies have recalled wicketkeeper Joshua Da Silva and top-order batter Amir Jangoo to their squad for the upcoming two-match Test series at home against Sri Lanka.
Pakistan claimed a convincing 4-wicket victory over Australia in the 3rd ODI at Gaddafi Stadium, Lahore, on Thursday wrapping up the chase with 49 balls to spare.
