Left-arm fast bowler Afridi returned figures of 4-51 in eight overs while fellow seamer Naseem Shah took 3-55 as visitors restricted the Windies to a total of 280 all out in Trinidad.
Opener Evin Lewis top-scored for the hosts with 60 while captain Shai Hope contributed 55 before Roston Chase struck 53 but the Windies could not capitalise after being in a strong position of 105-2 in the 19th over.
Pakistan were then in a spot of bother as they slipped to 180-5 in the run-chase despite a fighting 53 from skipper Mohammad Rizwan.
Nawaz and Talat then combined for a unbroken 104-run and took the attack to the Windies bowlers as the stand came in just 70 balls.
Nawaz struck 63 not out from 54 balls while Talat was unbeaten on 41 off 37 deliveries as Pakistan took a 1-0 lead with two matches still to play in the series.
Pakistan claimed a convincing 4-wicket victory over Australia in the 3rd ODI at Gaddafi Stadium, Lahore, on Thursday wrapping up the chase with 49 balls to spare.
Nathan Ellis took four wickets as Australia defended a target 232 to beat Pakistan by 41 runs in the second ODI in Lahore as the visitors levelled the three-match series with one game left to play.
Shimron Hetmyer has been "reintegrated" into West Indies' ODI squad ahead of the home series against Sri Lanka, starting on Wednesday, while fast bowler Alzarri Joseph also returns from injury.
Cricket West Indies unveiled an exciting schedule for the 2026 Men's International Home Series, setting the stage for an electrifying summer of cricket across the Caribbean.
