Left-arm fast bowler Afridi returned figures of 4-51 in eight overs while fellow seamer Naseem Shah took 3-55 as visitors restricted the Windies to a total of 280 all out in Trinidad.
Opener Evin Lewis top-scored for the hosts with 60 while captain Shai Hope contributed 55 before Roston Chase struck 53 but the Windies could not capitalise after being in a strong position of 105-2 in the 19th over.
Pakistan were then in a spot of bother as they slipped to 180-5 in the run-chase despite a fighting 53 from skipper Mohammad Rizwan.
Nawaz and Talat then combined for a unbroken 104-run and took the attack to the Windies bowlers as the stand came in just 70 balls.
Nawaz struck 63 not out from 54 balls while Talat was unbeaten on 41 off 37 deliveries as Pakistan took a 1-0 lead with two matches still to play in the series.
Justin Greaves says he will saviour a 'special day' after scoring a maiden double-century to help West Indies to an epic draw in the first Test against New Zealand in Christchurch.
New Zealand chased down a target of 162 to beat West Indies by four wickets to seal s clean sweep in the three-match ODI series at home.
The Proteas suffered a calamitous batting collapse as Pakistan claimed a seven-wicket win in the third and final ODI in Faisalabad on Saturday and with it a 2-1 series victory.
Quinton de Kock produced a batting masterclass as South Africa crushed Pakistan by eight wickets in the second ODI in Faisalabad, chasing down 270 with nearly 10 overs to spare to level the three-match series 1-1.
