Khaka and her teammates face India in Colombo on Tuesday before then playing host nation Sri Lanka at the same stadium on Friday.
The 32-year-old Khaka made her debut for Proteas more than 12 years ago and has gone on to take 131 wickets in 106 ODI appearances at an economy rate of 4.20, including career-best figures of 5-26 against West Indies in January 2022.
Her role as a mentor is vital for the current Proteas Women group, especially as more young players make their way into the national fold.
Mashimbyi said of his senior bowler: "Aya has been a stalwart for the longest time. Twelve years of international cricket. Wow, it's a huge achievement
"It will be hard to get something out of her that would suggest that she's excited about the feat, but I do know that she cares about the badge.
"Aya is the type of player who recognises those opportunities. She's someone who understands the significance of her role, not just as a player but as a mentor to those coming through."
Last year the Middledrift-born seamer made history as the first black African woman and only the third Black African cricketer to achieve a century of matches in the 50-over format.
Reflecting on her career, Khaka acknowledges the support she has received throughout the years.
She said: "My family has been there for me, my friends, and my community as well. Without them, I would not have been here.
"It doesn't matter where you come from, it's all about your goals and what you want to achieve. Everything is possible.
"I just enjoy putting the jersey on. I know there are a lot of people who want to be in my shoes. To be honest, when I'm done, I'll look down and think about those moments. For now, I'm just enjoying the moments and doing it for the country."
The Proteas women fell 14 runs short despite a spirited chase against India in the fourth T20I at Wanderers Stadium on Saturday, though they continue to lead the five-match series 3-1.
Proteas Women allrounder Chloe Tryon says they want to keep momentum in their performances in the final two T20Is against India despite already wrapping up the series.
Records tumbled all around Proteas Women captain Laura Wolvaardt as she powered South Africa to a series win over India in the third T20I on Wednesday.
Laura Wolvaardt delivered a batting masterclass for the ages as South Africa sealed the T20 International series against India with a crushing nine-wicket victory at the Wanderers on Wednesday night.
