The north London club have crafted a deal structure they believe will appeal to Palace, aiming to secure the 27-year-old before his release clause expires this week.
According to reports, Tottenham value Eze at around 55 million pounds, while Palace are holding firm at 68 million pounds – the figure tied to his soon-to-expire release clause.
Spurs have been in contact with Eze's representatives for over a week and are optimistic about personal terms, as the player has expressed keen interest in the move to play Champions League football.
Transfer expert Fabrizio Romano has said: "Tottenham are prepared to open formal negotiations for Eberechi Eze, with the player keen on the move as Palace have been informed of his desire."
Palace might reject the initial approach, but Tottenham are ready to respond swiftly, confident their framework can close the gap. Eze, who has dazzled with his creativity and goal-scoring from midfield, is likely to have featured in his final match for the Eagles, waiting for talks to progress.
Arsenal's reluctance has cleared the path for their rivals. The Gunners have hesitated over Eze, uncertain if he would displace captain Martin Odegaard in the No.10 role.
This indecision has left Eze more open to alternatives, handing Tottenham the advantage in what could be a statement signing to bolster their attacking options, especially with James Maddison sidelined by injury for much of the season.
In other Tottenham developments, the club are set to table an improved offer for Manchester City's winger Savinho after their initial 42 million pounds bid was turned down.
City are demanding around 67 million pounds for the Brazilian, but Spurs remain determined, with Savinho's agent confirming ongoing interest and the player's openness to the switch.
Meanwhile, Juventus have shown real interest in midfielder Yves Bissouma, potentially preparing a 23 to 25 million pounds offer as they seek reinforcements.
Tottenham, however, value the Malian highly and may resist any advances amid their midfield rebuild.
Aston Villa battled to a hard-fought 0-0 draw against Newcastle United in their Premier League opener at Villa Park, extending their unbeaten home run to 22 matches despite playing the final stages with ten men.
Manchester City have received an official opening bid from Galatasaray for their goalkeeper Ederson, potentially paving the way for a dramatic late-window swap involving Gianluigi Donnarumma.
Liverpool's Federico Chiesa delivered a moment of magic in their thrilling 4-2 win over Bournemouth, reigniting discussions about his future with the Premier League champions.
Liverpool launched their Premier League title defence with a pulsating 4-2 win against Bournemouth at Anfield, overcoming a spirited comeback to secure three points in a match charged with emotion.
