The visitors scored eight tries in total while Handre Pollard slotted six conversions as home team were put to the sword by their provincial rivals.
The Bulls started like a steam-train and went over for four tries in the first half with Harold Vorster, Johan Grobbelaar, Pollard and Kurt-Lee Arendse going over.
With a bonus-point already in the bag, the men in blue took a 26-3 lead into the halftime break.
Morne van den Berg gave Lions a glimmer of hope with a try just after the interval but that hope was short-lived.
The Bulls once again pulled clear on the scoreboard and further tries by Embrose Papier, and substitutes Mpilo Gumede and Keagan Johannes underlined their dominance.
The hosts managed a late consolation through centre Bronson Mills, but by that time the contest was already a foregone conclusion.
The Lions were left shell-shocked after a brutal 52–17 United Rugby Championship defeat to arch-rivals the Bulls at Ellis Park, a result that exposed major flaws despite recent signs of progress.
Stormers captain Sacha Feinberg-Mngomezulu accepted responsibility after his side's second successive defeat to the Sharks, admitting a lack of discipline proved decisive in the 36-24 loss at Kings Park on Saturday.
Sharks coach JP Pietersen and captain Andre Esterhuizen were full of praise for their teammates after they handed the Stormers a second consecutive loss on Saturday.
Johan Ackermann was a happy man after his Bulls team steamrolled the Lions 52-17 at Ellis Park on Saturday.
