The Buccaneers are in scintillating form, having secured a tough Soweto Derby victory over arch-rivals Kaizer Chiefs.
With 30 points from 12 matches, they are enjoying their best-ever start to a league season, winning 10 of those games. They currently sit second in the table, six points ahead of fourth-placed Sekhukhune.
Babina Noko, meanwhile, were held to a 1-1 draw against Stellenbosch in their last outing.
Their season has been solid, with seven wins, three draws, and four defeats in 14 matches, accumulating 24 points.
However, they face a tough challenge against Pirates, a side they have beaten just once in their last five meetings, drawing once and losing three.
Orlando Pirates have a full squad available, with no injuries or suspensions, giving coach Jose Riveiro plenty of options.
Sekhukhune, on the other hand, will be without Relebogile Katlego Mokhuoane and Siphesihle Elwin Mkhize due to suspension, potentially weakening their midfield.
The last encounter between these sides ended in a 1-0 win for Pirates, and given their current form, they will be favourites again.
Orlando Pirates clinched the Carling Knockout Cup in dramatic fashion at the New Peter Mokaba Stadium, edging Marumo Gallants 1-0 after extra time to secure their second trophy of the season.
Marumo Gallants' goalkeeper Washington Arubi says his side is comfortable being labelled the underdogs ahead of Saturday's Carling Knockout final against Orlando Pirates.
Kaizer Chiefs co-coach Khalil Ben Youssef has admitted his side continues to struggle in front of goal but insists the team is working hard to solve the problem ahead of Sunday’s clash with TS Galaxy in Mbombela.
Orlando Pirates face Marumo Gallants in the Carling Knockout Cup final at Peter Mokaba Stadium on Saturday as they attempt to win their second trophy this season.
