After being inserted to bat at the toss, the visitors piled on a total of 181-7 in their 20 overs with Muhammad Manack and Matthew De Villiers both scoring 54.
Returning from Proteas duty in Pakistan, Matthew Breetzke also contributed a handy 39 off 19 balls to place the Warriors in a strong position at the halfway stage.
The Tuskers lost wickets at regular intervals in pursuit of the target and were restricted to 127 all out in 18 overs.
Chad Laycock top-scored with 37 while Ntandoyenkosi Zuma struck 23 but little other contributions from the rest of the batting order.
The Warriors put in a disciplined bowling effort with Kerwin Mungroo, CJ King and wrist-spinner Thomas Kaber taking two wickets apiece.
The CSA T20 Challenge continues on Sunday with the Titans hosting the Lions in the Highveld derby in Centurion while Western Province take on the Dolphins at Newlands.
The Dafabet Warriors stormed to the top of the CSA T20 Challenge log on Wednesday night, hammering previously unbeaten Goldrush Boland by 98 runs and securing a bonus point in the process.
The Lions will not have the opportunity to defend their CSA T20 Challenge trophy after a defeat in a super over against North West Dragons in a thrilling contest at the Wanderers.
Boland preserved their perfect start to the CSA T20 Challenge with a nerve-shredding five-run victory over the Dolphins in Paarl on Friday evening.
WSB Western Province kept their CSA T20 Challenge playoff hopes alive with a commanding nine-wicket victory over the Moothee Ram Tuskers at the City Ground in Pietermaritzburg on Thursday.
