The 20-year-old beat the long-standing previously held by West Indies legend Chris Gayle, who scored an unbeaten 175 for Royal Challengers Bengaluru against the now defunct Pune Warriors in an IPL clash in 2013.
Pretorius, who last month became the youngest player to score a men's international T20 hundred with 102 against Namibia, was playing in his first game after returning to the field following a groin injury.
The left-handed batter wasted no time to get going in the Pro20 contest at the Mangaung Oval in Bloemfontein, hitting a four and six off the first two balls of the encounter before going on to reach his fifty in just 24 balls.
It took him only 16 more deliveries to get to his century, while his 150 came off 58 balls with Pretorius eventually finishing his knock with 15 fours and 13 sixes to get the Titans to an imposing total of 267-3 in 20 overs.
It was the second highest total in South Africa's domestic T20 tournament, behind the Titans' own 271-3 against the same opposition in 2022.
The Titans dismissed the home side for 143 to win the contest by a monumental 143-run margin to make it three wins from three in the tournament.
Beyers Swanepoel is expected to make his first appearance for the Titans when they face the Dolphins in the opening round of the First Class Series at SuperSport Park on Thursday.
Proteas star Lhuan-dre Pretorius raised his bat for a maiden unbeaten T20 century as the San Francisco Unicorns thumped MI New York by nine wickets in MLC 2026.
Western Province Women etched their name into the record books by securing a third consecutive Pro20 title in Durban on Friday after beating the Lions by four wickets in the final.
Lhuan-dre Pretorius found his form at the perfect moment as Paarl Royals ended Joburg Super Kings' SA20 campaign with a commanding 36-run win at Centurion on Thursday night.
