Cook has been selected in a bowling attack that includes fellow pacemen Josh Tongue and Gus Atkinson as well as spinner Shoaib Bashir while captain Ben Stokes is also expected to play a part with the ball after undergoing hamstring surgery in January.
The 27-year-old Cook has taken 321 wickets in 89 first-class matches at an average of less than 20 and benefits from the injury-enforced absence of Chris Woakes and the retirement of James Anderson.
"I'm obviously very excited about getting the nod and getting out there," Cook told reporters at Trent Bridge. "It's any young cricketer's dream to pull on the Test shirt for England.
"So it's something hopefully that comes to fruition and I'm really, really looking forward to it.
"I feel, at 27, a better cricketer for the experiences I've had in the game," he said. "I think the Lions programme and being in and around the Test set-up over the last few years has made that transition into the squad pretty seamless, and I felt very welcomed.
"The environment's been fantastic to be a part of. I'm just excited at the prospect of what's to come and trying to get stuck in and take some wickets."
England Test XI: 1 Zak Crawley, 2 Ben Duckett, 3 Ollie Pope, 4 Joe Root, 5 Harry Brook, 6 Ben Stokes (capt), 7 James Smith (wk), 8 Gus Atkinson, 9 Josh Tongue, 10, Sam Cook, 11 Shoaib Bashir
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England captain Harry Brook says his dropped off catch off Sanju Samson went a long way to his team losing their T20 World Cup semifinal against co-hosts India in Mumbai.
Sam Curran feels England need to be on top of their game if they are to beat India and silence the home crowd in Thursday's T20 World Cup semifinal in Mumbai.
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