It will be 17-year-old Meso's - who has two ODI caps - maiden senior global tournament after competing in two U19 Women's T20 World Cups in 2023 and 2025 and will vie for the wicketkeeper role with Sinalo Jafta.
The 15-player squad will be captained by Laura Wolvaardt, and includes the experienced quartet of Chloe Tryon, Marizanne Kapp, Ayabonga Khaka and Sune Luus.
In the bowling ranks, left-arm spinner Nonkululeko Mlaba leads the spin attack while Masabata Klaas and Tumi Sekhukhune offer varying seam options.
Young all-rounder Miane Smit has been named as the travelling reserve, a role she performed during last year's Women's T20 World Cup.
Proteas Women head coach Mandla Mashimbyi said: "What a journey it has been. From the moment I joined this team, and even before my time when the squad went through the qualification phase, it was all about working towards this moment.
"We can look back at the amount of preparation we have put in and know that we have done our best. We are ready to send a squad to the World Cup that will make South Africa proud.
"I am happy for all the players and management who will be getting on that plane to India, but I am even more excited to see what they can achieve together as a group. We believe we have the squad of players that can go out there and deliver on the world stage.
"Now it is all about carrying that belief with us every step of the way, along with the support of the entire nation."
The Proteas Women will get their World Cup campaign underway against England on 3 October, followed by encounters against New Zealand, India, Bangladesh, Sri Lanka and Pakistan before concluding the league phase with a contest against Australia on 25 October.
Proteas Women World Cup squad: Laura Wolvaardt (captain), Anneke Bosch, Tazmin Brits, Nadine de Klerk, Annerie Dercksen, Sinalo Jafta, Marizanne Kapp, Ayabonga Khaka, Masabata Klaas, Sune Luus, Karabo Meso, Nonkululeko Mlaba, Tumi Sekhukhune, Nondumiso Shangase, Chloe Tryon
Travelling reserve: Miane Smit
Former South Africa captain Dane van Niekerk has been named in the extended Proteas Women's training squad ahead of the Women's Cricket World Cup, as the team prepares for a critical tour of Pakistan and the global showpiece in India and Sri Lanka.
As the countdown to the 2025 ICC Women's ODI World Cup gathers momentum, the Proteas Women are gearing up for a vital away series against Pakistan - a key step in their preparations for global competition.
Cricket South Africa (CSA) has confirmed that the Proteas men and women's teams will play a five-match T20I series of double-headers in New Zealand in March 2026.
Proteas Women's opener Tazmin Brits has climbed to career-best positions in both the ICC T20I and ODI batting rankings after a superb run of form on the tour of the West Indies.
