Mikel Arteta's side could be without Declan Rice, Jorginho, Leandro Trossard and Kai Havertz - though all four have returned to training and may yet feature.
The stakes could hardly be higher, with Newcastle knowing that a win would lift them above the Gunners into second place with just one match remaining in the Premier League season.
The visitors arrive in confident mood following a spirited comeback against the champions last weekend and will be looking to claim their fourth win over Arsenal this campaign.
A midfield depleted by injuries could tilt the balance in Newcastle's favour, especially if Rice - who has been in inspired form of late - fails to make the cut.
His absence would be a major blow to Arsenal's control in the centre of the pitch and a boost to Newcastle's ambitions.
Adding to Arsenal's selection problems, former Newcastle midfielder Mikel Merino is suspended after receiving a red card in the loss to Liverpool, further limiting Arteta's options.
Arsenal have reportedly set their sights on Brighton's dynamic forward Joao Pedro as they aim to revitalise their attacking options for the upcoming season, according to multiple sources.
Arsenal's push for a strong Premier League finish has taken a significant hit, with manager Mikel Arteta admitting Declan Rice's injury "does not look good" following his absence in Sunday's intense 2-2 draw with Liverpool at Anfield.
Premier League champions Liverpool were held to a thrilling 2–2 draw by Arsenal at Anfield, as the visitors mounted a spirited second-half comeback after falling behind early.
Mikel Arteta has acknowledged that Arsenal entered the 2024–25 campaign knowing their squad lacked depth and included several players prone to injury - limitations that ultimately contributed to another trophyless season.
