Coach Hugo Broos and his squad will host the West African side, who failed to qualify for the tournament for the first time since 2004, at a venue to be confirmed.
Regardless of the location, a strong crowd is expected, as South African fans rally behind Bafana, fresh off securing qualification for next year's FIFA World Cup in the US, Mexico, and Canada.
The national team will depart for Morocco the following day to begin their AFCON campaign, which runs from December 21 to January 18. The tournament will see teams compete to dethrone defending champions Ivory Coast.
Bafana, bronze medallists at last year's Nations Cup in Ivory Coast, are drawn in Group B.
They open their campaign against Angola in Marrakesh on December 21, before facing Egypt in Agadir on December 26, and concluding the group stage against Zimbabwe in Marrakesh on December 29.
The friendly against Ghana is seen as a crucial warm-up, giving Broos a chance to fine-tune his squad and test tactics ahead of the competitive fixtures.
Hugo Broos has named a 38-man preliminary squad for South Africa national football team ahead of international friendlies against Panama national football team later this month, giving several overlooked players another chance to impress.
Orlando Pirates veteran midfielder Makhehleni 'Cash' Makhaula believes the club's rising stars could form the backbone of Bafana Bafana's squad at the 2026 FIFA World Cup.
Ghana forward Antoine Semenyo has explained how he has been able to adjust to Manchester City following his January transfer window move from Bournemouth.
Bafana Bafana's kit for the upcoming World Cup has been unveiled by the South African Football Association.
