Raphinha remains sidelined with a hamstring injury picked up last month, and Ferran has not recovered from discomfort sustained during international duty. Both missed recent training sessions and are not expected to be risked midweek.
Their absences come on top of a growing injury list that includes Robert Lewandowski, Gavi, Dani Olmo, and Joan Garcia. Andreas Christensen is also a doubt after leaving training due to discomfort.
Flick now faces limited attacking options. Lamine Yamal and Fermin Lopez could play bigger roles, while new signing Roony Bardghji may get minutes. In a pinch, Ronald Araujo could even be used in a forward role.
With Olympiacos in the Champions League and Real Madrid looming in El Clasico, Barca must navigate two crucial fixtures without several key players - a serious test of their depth and resilience.
Real Madrid coach Alvaro Arbeloa has insisted his side would continue fighting for the La Liga title despite recent setbacks, as pressure grows on the former defender following two damaging league defeats.
FC Barcelona manager Hansi Flick has been forced to rethink his defensive plans after losing two key players to injury during the club's dramatic Copa del Rey semi-final clash with Atletico Madrid.
Real Madrid forward Rodrygo will miss the rest of the season and the 2026 World Cup after suffering a serious knee injury in Monday's 1-0 LaLiga defeat to Getafe CF.
Barcelona were eliminated from the Copa del Rey at the semi-final stage despite winning the second leg at Camp Nou, as Atletico Madrid progressed with a 4-3 aggregate victory.
