Raphinha remains sidelined with a hamstring injury picked up last month, and Ferran has not recovered from discomfort sustained during international duty. Both missed recent training sessions and are not expected to be risked midweek.
Their absences come on top of a growing injury list that includes Robert Lewandowski, Gavi, Dani Olmo, and Joan Garcia. Andreas Christensen is also a doubt after leaving training due to discomfort.
Flick now faces limited attacking options. Lamine Yamal and Fermin Lopez could play bigger roles, while new signing Roony Bardghji may get minutes. In a pinch, Ronald Araujo could even be used in a forward role.
With Olympiacos in the Champions League and Real Madrid looming in El Clasico, Barca must navigate two crucial fixtures without several key players - a serious test of their depth and resilience.
Jose Mourinho has criticised the Spanish football authorities over their handling of Vinicius Junior's suspension after Real Madrid fought back from two goals down to beat Roma 4-3 in the Champions League.
Real Madrid produced a remarkable late comeback to beat Roma 4-3 at the Stadio Olimpico, scoring three times in the final stages to snatch victory after trailing 3-1.
Real Madrid forward Vinicius Junior will miss the first El Clasico of the season after receiving a four-match suspension following his red card against Villarreal.
Brajan Gruda is determined to earn another Germany call-up after an injury setback disrupted his international ambitions, with the RB Leipzig midfielder making an immediate statement on his return to action.
