Bayern have an eight-point lead at the top of the Bundesliga standings with just three games of the season remaining, meaning Bayer Leverkusen in second need to win all of their remaining fixtures to stand any chance of challenging for the title.
The Bavarians, on the other hand, need just a single point from their remaining three games to secure the championship for themselves in what would be star striker Kane's first-ever league trophy.
Leroy Sane opened the scoring for Bayern in the 24th minute against Mainz before Olise doubled their advantage 13 minutes later.
Despite their complete dominance for the entire game, it took until the 84th minute before the result was entirely secure when Eric Dier made it 3-0.
Elsewhere in the Bundesliga on Saturday, Mathias Honsak's solo effort was enough to secure a 1-0 win for Heidenheim at Stuttgart and goals by Patrik Schick (13') and Emiliano Buendia (45+1) handed Leverkusen a 2-0 victory over Augsburg.
Frankfurt took full advantage of an El Chadaille Bitshiabu red card to thrash RB Leipzig 4-0 with Ansgar Knauff (21', 53'), Hugo Ekitike (67') and Robin Koch (71') all getting on the scoresheet.
Max Rosenfelder scored the only goal of the game as Freiburg beat 10-man Wolfsburg 1-0 while Dortmund needed a late Waldemar Anton goal to secure a dramatic 3-2 win at Hoffenheim.
Without question, the match of the day in the Bundesliga on Saturday was Kiel's thrilling 4-3 win over Borussia Monchengladbach.
Shuto Machino was named Man of the Match after scoring both the opening and final goals of the game in the 15th and 91st minutes respectively.
Sandwiched between those were strikes by Alexander Bernhardsson (23'), Tomas Cvancara (60'), Alassane Plea (69'), Armin Gigovic (76') and Franck Honorat (86').
Borussia Dortmund and Hamburger SV were the big winners in a dramatic Bundesliga round, as Dortmund beat TSG Hoffenheim 2-0 at the Westfalenstadion and Hamburg edged SV Werder Bremen 3-2 in a Nordderby at the Volksparkstadion.
Saturday proved to be a goal-fest in the Bundesliga as the top two sides in the standings blew away their opposition to pull further away from the rest.
VfB Stuttgart will aim to maintain their strong home record when they host Bundesliga leaders Bayern Munich this weekend.
Aleix Garcia is enjoying the best spell of his career, turning himself into a key figure in Bayer Leverkusen's midfield and pushing for a place in Spain's 2026 World Cup squad.
