It was the visitors that twice came from behind to leave Durban with a point as the pressure ramps up at the end of the season approaches.
It was Usuthu that took the lead in front of their own fans when Thapelo Matlhoko headed home in the 23rd minute.
Sekhukhune hit back though and found the equaliser four minutes before the halftime break as Olerato Mandi netted.
The visitors had early opportunities after the break to take the lead but Lehlogonolo Mojela and Ellis Rammala could not capitalise.
Eric Tinkler's charges would rue those missed chances as Amazulu went back in front when Nkosikhona Radebe found the back of the net.
Sekhukhune however would the deny the home team taking maximum points from the contest when Bright Ndlovu made it 2-2 with 12 minutes remaining.
Both sides will be in league action again on Saturday, with AmaZulu facing Siwelele in Bloemfontein, while Sekhukhune host relegation-threatened Magesi in Polokwane.
Kaizer Chiefs will look to extend their impressive winning streak when they face struggling Magesi FC in a Betway Premiership clash at the Peter Mokaba Stadium on Wednesday evening.
Sekhukhune United have reportedly parted ways with head coach Eric Tinkler.
Junior Khanye has thrown his weight behind Mamelodi Sundowns defenders Keanu Cupido and Grant Kekana, insisting their recent performances have made a strong case for inclusion in the South Africa national football team.
Papi Zothwane has poured cold water on any hopes that Richards Bay FC will play a decisive role in the Betway Premiership title race, stressing that his team’s priorities lie elsewhere.
