Chelsea take on Pep Guardiola's side in a 15h00 kick-off at the national stadium with the chance to win the FA Cup and end the season with major silverware.
McFarlane knows Chelsea's attacking players could be decisive against City, with both Pedro and Palmer expected to play key roles in breaking down one of the toughest defences in English football.
Brazil international Joao Pedro is likely to lead the line after impressing in several attacking roles during his first season at Stamford Bridge. Although he has also operated as a No10, the forward has increasingly settled into the central striker role in recent months.
Speaking at Cobham ahead of the final, McFarlane praised Pedro's progress and backed him to continue his strong form on the biggest stage.
"Joao's had a great year," McFarlane said.
"He's played many different positions, but he seems to have settled into that No9 role, and he's got everything you'd want from a top No9.
"It's a big summer coming up for him with the World Cup with Brazil, but he's been excellent for Chelsea, and hopefully he continues that for the last three games."
Cole Palmer is also expected to be central to Chelsea's plans at Wembley. The England international has switched between a central attacking role and the right flank this season while also managing injury problems.
McFarlane was encouraged by Palmer's display in last weekend's 1-1 draw at Liverpool and hopes the midfielder can produce another big performance against City.
"He's had some really good games for us this year," McFarlane added.
"He's had a lot of injuries that he's had to deal with, but I was really pleased with Cole on Saturday.
"I thought he had moments where he showed his level and his quality and we're really hopeful Cole can produce that from now to the end of the season."
With Wembley preparing for another major final, Chelsea will look to Palmer and Pedro to provide the quality needed to overcome Manchester City and lift the famous trophy on Saturday.
Seamus Coleman has confirmed he will bring the curtain down on his playing career at Everton when his contract expires next month, closing the book on more than 17 years of service at Goodison Park.
Liverpool captain Virgil van Dijk has admitted the club's season has fallen below expectations, describing their performances as "unacceptable" while urging the squad to respond strongly in the final two matches and into next season.
Mikel Arteta has insisted Arsenal will block out the title race noise and focus only on beating Burnley when they return to Premier League action in their final home match of the season on Monday.
Manchester City manager Pep Guardiola has revealed his FA Cup final plans after rotating heavily during Wednesday night's Premier League win over Crystal Palace.
