The Super Eagles are in third position in Group C, three points behind Benin and South Africa, needing to win both matches and hope for Bafana Bafana to lose in order to secure qualification.
"Everybody can go to the World Cup," said head coach Chelle ahead of Lesotho clash.
"This is football, anything can happen during the game because of the weather, the referee, injuries, or other factors. So, we need to stay focused on what we want from this game."
Nigeria will be boosted by the return of Galatasaray star striker Victor Osimhen who missed the 1-1 draw against South Africa last month after suffering an injury in the previous match.
“We want to have this victory, and after that, there will be another game. So, for sure, we must be 100% focused on this match tomorrow against Lesotho, a great team with a good coach,” added Chelle.
"We need to start well, with a lot of intensity and aggressiveness, to score and to win this game."
The Super Eagles will face the Crocodiles at the Peter Mokaba Stadium on Friday before hosting Benin at the Godswill Akpabio Stadium on Tuesday.
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