The changes, which form part of amendments to FIFA's Regulations on the Status and Transfer of Players, will require clubs and footballers to include buyout amounts in their agreements, allowing either side to end a contract by activating the clause.
While such provisions are already commonplace in Spain, they will now be introduced across the Premier League and other competitions worldwide.
Spanish clubs have long used exceptionally high figures as protection, with Barcelona star Lamine Yamal reportedly carrying a one billion euro clause.
The deal also strengthens FIFPRO's role within the sport's governance structure. The union has been formally recognised as the worldwide representative body for professional footballers and will gain a seat on the FIFA Council, along with representation on legal committees.
In addition, FIFPRO will hold veto rights in key governance matters. The memorandum, confirmed by FIFA president Gianni Infantino, will remain in effect until December 2031.
FIFPRO president Sergio Marchi said: "This agreement represents an important step forward for football. Ensuring that players and their representatives have a meaningful voice in decisions affecting their careers is not only beneficial for footballers, but for the game as a whole."
The agreement follows the resolution of several legal disputes, including Lassana Diarra's long-running case involving FIFA and the Royal Belgian Football Association.
FIFA said the arrangement was contingent on FIFPRO withdrawing its legal actions, including a 2024 complaint concerning fixture congestion.
"It's about unity, about bringing everyone together," FIFA president Gianni Infantino said.
"We've always been having dialogues. Now, sometimes you don't agree, when you don't agree, well, you can go and say it to everyone, or you can sit down and discuss and see what makes sense. So, we signed a memorandum of understanding with FIFPRO, everything is agreed."
Players will also benefit from enhanced protections against abusive treatment, greater rights to terminate contracts while recovering unpaid wages, and compensation claims that can include up to six months' additional salary.
Furthermore, from next year, lower-paid players earning under 150,000 euros annually will receive a share of transfer fees, mirroring a system already used in Spain.
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