Yamal was at the heart of Spain's impressive display, scoring twice and providing an assist before being substituted for Victor Munoz in the 68th minute.
The victory was Spain's second in the group after they opened their campaign with a 3-2 win over England at Wembley last weekend.
De la Fuente, who admitted that he prefers not to focus too much on individual performances, could not ignore Yamal's contribution against Croatia.
"I don't like to focus too much on individual performances, but sometimes it's impossible not to do so," De la Fuente said of Lamine Yamal following the match as quoted by BBC.
"Lamine wants to show the world the kind of player he is. Today (Tuesday) we enjoyed his magic again, but he puts his magic at the service of the team. That says a lot about the player. In the future he'll be even more well known for what he does in his collective play.
"We're lucky to have him with us. Within the group, he's very loved."
The result leaves the World Champions at the top of their group as they continue their pursuit of a second UEFA Nations League title.
Spain will return to action on Saturday when they host Czech Republic in Oviedo before travelling to face Croatia next Tuesday night.
Other results:
Finland 0-0 Belarus
Moldova 1-1 Faroe Islands
Luxembourg 0-3 Iceland
Slovakia 2-1 Kazakhstan
Czech Republic 0-2 England
Slovenia 2-0 North Macedonia
Bulgaria 0-0 Estonia
San Marino 0-3 Albania
Scotland 0-3 Switzerland
Jonas Urbig is relishing the chance to make his Germany debut at Bayern Munich's Allianz Arena after being told he will start against Serbia in the UEFA Nations League tonight.
Lamine Yamal's former Barcelona youth coach Ivan Carrasco believes the teenage star has still not shown the full extent of his potential.
Jurgen Klopp has suffered another setback ahead of Germany's UEFA Nations League clash with Serbia after Nico Schlotterbeck was ruled out through injury.
Anthony Gordon and Harry Kane were on target as England bounced back from an opening defeat to beat 10-man Czech Republic 2-0 in their UEFA Nations League clash in Prague.
