The German side will be making their first trip to the country as part of the "RE KAOFELA" tour.
Sundowns confirmed the news with a post on their website, as Leipzig General Manager Johann Plenge described South Africa as an "exciting football market".
The Brazilians posted: "RB Leipzig is setting another strong international marker and will travel to South Africa for the first time in the club's history. As part of the tour "RE KAOFELA" (English: all together), the Red Bulls will be hosted in Johannesburg from 26 to 30 May 2026 – a significant milestone for RB Leipzig and the club's third major international tour after previous trips to the USA in 2024 and Brazil in 2025.
"The sporting highlight of the tour will be a friendly match against Mamelodi Sundowns, champions of the Premier League in South Africa, on 29 May 2026 in Pretoria. The match against the participant of the 2025 FIFA Club World Cup will kick off at 20:00 local time at the historic Lucas Moripe Stadium. The game will be broadcasted live by SABC3, Bundesliga media partner in the market.
Plenge added: "South Africa is a particularly exciting football market and a culturally impressive destination for RB Leipzig and the Bundesliga. The passion with which football is lived here fits perfectly with our goal of inspiring people around the world with our intensive and attacking style of play, as well as with our football as a whole.
"After successful tours in the United States and Brazil, we are now very much looking forward to once again taking on responsibility for the league, traveling to South Africa for the first time, and meeting Mamelodi Sundowns – a club that has shaped African football for years and enjoys significant international recognition. We carry the colors of our club and our city out into the world and want to be the best possible ambassadors for Leipzig.
"For us, this trip is a valuable opportunity to engage with South African fans, gain insights into the local football culture, and continue to expand our international identity."
Sundowns have previously hosted La Liga giants Barcelona, twice, first at Loftus Versfeld in June 2007, where they lost 2-1, and in May 2018, losing 3-1 at the FNB Stadium.