The 20-year-old limped off with what looks like an ankle problem and will miss their next Bundesliga match against Union Berlin on Friday, and is unlikely to return before their final game of 2025 against Bayer Leverkusen on December 20.
Nusa had been showing promise this season: he recorded two goals and two assists in 15 appearances.
His absence deepens Leipzig's growing list of injury troubles. Midfielder Assan Ouédraogo is already sidelined with a knee tendon problem ruled to put him out for weeks.
Also unavailable is forward Rômulo Cardoso, who is still struggling with a persistent knee issue.
Despite the setbacks, head coach Ole Werner remains optimistic, stressing that the squad still has the depth and quality to cope: "We are in a situation where we must adapt, but we have players ready to step up," Werner said.
With players like Yan Diomande, Loïs Openda and Benjamin Sesko still fit, and fresh off a dominating win over Frankfurt, Leipzig stay second in the Bundesliga and will be hoping to weather this tough spell without losing ground.
Liverpool head to the San Siro tonight looking to achieve a feat only Bayern Munich have managed in the Champions League era, winning three away matches against Inter Milan in the competition.
Hansi Flick has stated that Barcelona's defending has reached "another level" after a strong run of results lifted confidence across the squad ahead of their Champions League clash with Eintracht Frankfurt tonight.
Vincent Kompany has said Alphonso Davies could be included in Bayern Munich's squad for their Champions League match against Sporting CP tonight, as the Canadian edges closer to his long-awaited return.
Borussia Dortmund and Hamburger SV were the big winners in a dramatic Bundesliga round, as Dortmund beat TSG Hoffenheim 2-0 at the Westfalenstadion and Hamburg edged SV Werder Bremen 3-2 in a Nordderby at the Volksparkstadion.
