Snyman, who currently plays for Leinster after five seasons with Munster, will line up against several familiar faces. Ireland coach Andy Farrell has selected 21 Leinster players in his 34-man squad for the end-of-year series.
"It will be very special to play against Ireland because it has been such a big part of my career," Snyman said. "I have a lot of friends here. You always put in a little bit extra because you want their respect."
The 30-year-old made his Bok debut in 2018 against England at Ellis Park but saw his international progress halted for more than three years due to major injuries. His setbacks included two ACL ruptures, a sternum injury, and severe burns from an off-field incident during his early years at Munster.
Since featuring in the 2019 World Cup final, he did not play another Test until July 2023. His 49th appearance came last weekend in South Africa's 32–14 win over Italy in Turin.
"The injuries made me stronger. It was the hardest time of my life," Snyman said. "I'm stronger psychologically now. I'm desperate to wear the Bok jersey every week."
Saturday's match will be the Springboks' fourth fixture of their European tour, following victories over Japan, France and Italy. After facing Ireland, they will conclude their season against Wales in
Cardiff before the world rankings determine the 2027 Rugby World Cup pools.
Snyman said the possibility of reaching the milestone against his club teammates adds significance.
"Playing at Aviva would be really special," he said. "When you play against people you know well, you want to earn their respect. You will always go a little bit harder."
The lock said he has not spent much time thinking about reaching 50 caps, especially after the squad recently celebrated Siya Kolisi's 100th.
"I'm taking it week by week," Snyman said. "It would be incredible to play my fiftieth because I missed so many Tests."
Springbok utility back Canan Moodie says Saturday's 32-14 win over Italy showcased the Springboks' resilience and "South African-ness" as they prepare for a crucial Test against Ireland in Dublin.
The Springboks will host England, Scotland, and Wales next year as the southern and northern hemispheres embark on the groundbreaking new Nations Championship.
Damian Willemse has revealed that talk of South Africa sending a second-string team to face Italy fired up the players, calling the narrative "disrespectful" after their hard-fought victory in Turin.
Springboks head coach Rassie Erasmus has called up experienced hooker Bongi Mbonambi and loosehead prop Ntuthuko Mchunu to strengthen his front-row department ahead of next weekend's Test against Ireland.
