Manager Rúben Amorim has provided updates on all three as the Red Devils look to maintain their strong home form.
Forward Benjamin Sesko limped off during the 2-2 draw with Tottenham before the international break and is expected to be out for several weeks. Amorim described the knee problem as "not that serious" but emphasized caution:
"He is going to stay a few weeks out. I don't know how long, but it is not that serious. He's feeling better, and in a few weeks, I expect to have Ben back."
Centre-back Harry Maguire continues to recover from injury and will miss the Everton clash. Amorim confirmed the defender is "not ready" to return, forcing United to consider alternative options in central defense.
Midfielder Kobbie Mainoo missed training on Friday but is expected to rejoin the squad on Saturday. Amorim offered cautious optimism:
"Kobbie didn't train today, but maybe tomorrow. We'll see."
Arsenal have suffered a significant blow with the news that defender Gabriel Magalhaes will "be out for weeks" after picking up an injury on international duty with Brazil, as confirmed by manager Mikel Arteta.
Manchester City manager Pep Guardiola said the decisive phase of the Premier League campaign begins this weekend as his team attempts to close the gap on leaders Arsenal.
Chelsea will be without Cole Palmer for a crucial run of upcoming fixtures after the forward fractured his toe in a freak accident at home.
Ruben Amorim says joining Manchester United was the best decision of his career, even as he reflects on a turbulent first year at Old Trafford.
