Jayden Adams opened the scoring in the 11th minute, setting the tone for the match.
Tashreeq Matthews added two more goals to seal the win, with assists coming from key players like Lucas Ribeiro Costa and Peter Shalulile.
Sundowns have now won five of the last seven Tshwane Derbies, underlining their supremacy in the fixture.
Their current league form is equally impressive, with 13 wins from 14 matches, keeping them six points clear at the top of the table.
Meanwhile, SuperSport United, once a dominant force in South African football with three consecutive league titles over two decades ago, are now focused on youth development and selling talent.
Their last derby win came courtesy of Tapelo Maseko, who has since joined Sundowns.
Coach Miguel Cardoso made strategic substitutions, resting playmaker Marcelo Allende in preparation for Sundowns' crucial top-of-the-table clash against Orlando Pirates.
Pirates, who defeated Sekhukhune United 2-0 in Polokwane, remain in pursuit of the league leaders.
Former Kaizer Chiefs winger Joseph Malongoane has urged Amakhosi supporters to remain patient with co-coaches Khalil Ben Youssef and Cedric Kaze, arguing that the pair needs time to understand the unique demands of South African football.
Kaizer Chiefs co-coach Khalil Ben Youssef has admitted his side continues to struggle in front of goal but insists the team is working hard to solve the problem ahead of Sunday’s clash with TS Galaxy in Mbombela.
Orlando Pirates captain Nkosinathi Sibisi is keeping his focus sharply on the Carling Knockout Cup title as his team tops the Betway Premiership table with 28 points after 12 games.
Golden Arrows head coach Manqoba Mngqithi has praised a select few PSL teams for their progressive style of play while criticising the majority for adopting what he calls "negative football."
