The title race is tight, with Madrid just one point behind the Catalan side after 22 matches, while Valencia battles near the relegation zone in 16th place.
Los Blancos head to Mestalla with several key absences in attack. Jude Bellingham remains sidelined through injury, Vinicius Junior is suspended, and Rodrygo is out with a recent setback.
Despite the attacking worries, Real Madrid receive a major boost in defence with Trent Alexander-Arnold set to return.
The 27-year-old right-back last played in December against Athletic Club and has been out following a complicated injury. The club has been clear that Alexander-Arnold remains a key part of their long-term plans, and he is expected to start against Valencia.
His return could stabilise the defence and allow Federico Valverde to move back into midfield, restoring balance to the side.
Other defenders such as Dani Carvajal and Antonio Rudiger remain doubts, but the squad is bolstered by the possible inclusion of David Alaba and Ferland Mendy.
Real Madrid will also rely on Kylian Mbappé, who leads La Liga with 22 goals this season. With the title race so close, every point counts, and a win at Mestalla would keep Madrid within striking distance of Barcelona while putting pressure on the leaders.
For Valencia, the clash represents a vital chance to move away from the relegation zone.
With both the championship and survival stakes high, the game promises intensity, and all eyes will be on Alexander-Arnold as he returns to action for Real Madrid.
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