Bradley captained the 2025 contest at Bethpage Black, where Luke Donald's European side dominated the opening two days before sealing a 15-13 victory, successfully defending their title on American soil.
Europe's triumph marked the first away win for either team since the 2012 "Miracle at Medinah," and questions were raised about Bradley's pairings and course setup following the home loss.
Speaking publicly for the first time since the defeat, Bradley addressed the media at the Travelers Championship: "You win, it's glory for a lifetime. You lose, it's 'I'm going to have to sit with this for the rest of my life.
"There's no part of me that thinks I'll ever get over this. Since the Ryder Cup to now has been one of the toughest times in my life."
Team USA delivered a record-tying singles performance on the final day, claiming 8.5 points and mounting a near-historic comeback after Europe had established a seven-point lead over the opening two days.
"You put so much into it, and you have all this planning, and the first two days went as poorly as we could have ever thought," Bradley added. "Then we had that amazing rally on Sunday.
"What I've tried to take away is the incredible memories I had with the guys - the times in the locker room and the emotional times we had together."
Bradley said he is still trying to shake off the "Ryder Cup fog" and refocus on his PGA Tour career, though he remains hopeful about representing Team USA again in the future.
"I really would enjoy playing in one more [Ryder Cup]," Bradley admitted. "I don't know if I'll get the chance.
"This effing event has been so brutal to me. I don't know if I want to play. No, I do. It's such a weird thing to love something so much that just doesn't give you anything."