The series will get underway with two fixtures at Kingsmead Stadium in Durban on 17 and 19 April, followed by two matches at the Wanderers on 22 and 25 April.
The series will conclude with the fifth and final T20I at Willowmoore Park in Benoni on 27 April.
The series will South Africa's final assignment ahead of the T20 World Cup that will take place in England from 12 June.
At the global tournament, the Proteas Women have been drawn in Group 1 alongside Australia, Pakistan, India and two teams from the qualifiers.
Enoch Nkwe, CSA director of national teams and high performance, said: "Facing a team of India’s quality so close to a World Cup is exactly what the Proteas Women need at this stage of the preparation.
"It gives them an opportunity to test themselves against a top-level opponent, fine-tune their combinations and ensure they are executing their plans under pressure.
"This series will play a key role in sharpening the team’s readiness ahead of the T20 World Cup."
New Zealand put in a much improved display to beat a India by 50 runs in the fourth T20I in Visakhapatnam but the tourists still find themselves 3-1 down in the series with one game remaining.
Former India head coach Rahul Dravid says the lack of preparation for Test cricket has contributed to the team's recent struggles in the longest format of the game.
India drew first blood in the five-match T20I series against New Zealand after a comfortable 48-run victory in Nagpur on Wednesday.
New Zealand secured a thrilling 41-run victory to win the final match of the series and mark their first-ever ODI series win in India in Indore on Sunday.
