Chasing a target of 130, Pakistan got off to a sensation start as Mohammad Abbas dismissed Ben Duckett with the very first ball of the day, before the seamer trapped fellow opener Emilio Gay lbw for a duck to leave the hosts tottering on 2-2.
England captain Joe Root and number 3 Jordan Cox then brought a sense of calm to the crease to nullify a fired-up Pakistan bowling attack.
The home skipper did get a reprieve on 26 when he was bowled by Mohammad Ali off an inside edge, but was called back after the third umpire let it be known that the seamer had overstepped for no-ball.
Cox and Root then saw England over line with both scoring unbeaten half-centuries, Cox 59 not oout while his captain was on 62 when the winning runs were scored just before lunch interval.
Pakistan will rue the fact that they only scored 133 all out in the first innings, while England replied with 453 to a big lead into the rest of the contest.
The tourists did improve with the bat second time around, getting to 449 all out, thanks largely to an outstanding 81 from just 63 balls from debutant number 9 Razaullah, to at least give them some hope.
England completed a clean sweep of victories in the three-match T20I series against Sri Lanka after a convincing eight-wicket win in the final clash at Old Trafford on Sunday.
Pakistan pace bowler Haris Rauf is hoping to earn another opportunity in Test cricket as the national side prepare for their next ICC World Test Championship assignment.
Brendon McCullum has issued a warning to Brydon Carse to get his "house in order" if he wants to resurrect his international career with England.
England Test coach Stephen Fleming will join the white-ball squad for the T20I series against Sri Lanka that starts in Southampton on Tuesday.
