Amakhosi have tough opponents with two-time winners Zamalek and fellow Egyptian outfit Al Masry while Zambian side Zesco United complete Group D.
It will be the Soweto Giants' first foray into a continental tournament since their 2021 CAF Champions League campaign where they reached the final before losing to Al Ahly.
Stellies, who were semi-finalists in the competition last season, were drawn in Group C alongside Sead Ramovic's CR Belouizdad, AS Otoho and Singida Black Stars.
Steve Barker's charges surprised a host of team in Africa in what was their maiden continental campaign last time out before bowling out in the last four to Simba.
The group stages of the CAF Confederation Cup is set to kick off on the weekend of 21-23 November.
Mamelodi Sundowns maintained their lead at the top of the Betway Premiership, while there were also wins for Siwelele FC and Durban City in Wednesday night's domestic action.
Orbit College head coach Pogiso Makhoye admits his side struggled to contain a rampant Kaizer Chiefs in their Betway Premiership clash at the FNB Stadium on Tuesday.
Kaizer Chiefs interim co-head coach Cedric Kaze lauded his players following their 4-1 Betway Premiership victory over Orbit College at the FNB Stadium on Tuesday night.
Kaizer Chiefs moved up to second on the Betway Premiership standings with their win on Tuesday night, as new Chippa coach Vusumuzi Vilakazi picked up a point from his second game in charge.
