The forward picked up the injury during Madrid's 1-1 draw with Real Betis on Friday, where he was forced off in the 82nd minute. Real Madrid confirmed on Monday that scans revealed a hamstring problem, although the club did not provide a fixed recovery timeline, saying instead that his return will depend on how the injury develops over the coming days.
Spanish reports suggest the issue is not expected to be long-term, but with the Clasico scheduled for May 10 at Camp Nou, time is now tight for the France international to recover fully.
Mbappe has already had interruptions to his season due to a knee problem earlier in the campaign, and this latest setback adds further concern for both club and country, with the 2026 World Cup approaching in June.
Madrid head into a crucial final stretch of the La Liga season trailing Barcelona by 11 points with five matches remaining. Their schedule leaves little room for error, beginning with an away trip to Espanyol on May 3, followed by the high-stakes meeting with Barcelona a week later.
The campaign then closes with a demanding run of fixtures against Real Oviedo, Sevilla, and Athletic Club.
The next few days will be decisive in determining whether Madrid's key attacker can recover in time for one of the defining matches of their season.
Bukayo Saka has said Arsenal would head into next week's Champions League semi-final second leg with confidence after securing a hard-fought draw away to Atlético Madrid in Spain.
Tottenham winger Xavi Simons has already begun his road to recovery after suffering a serious knee injury that will keep him out for several months.
Granada and Algeria goalkeeper Luca Zidane suffered a serious facial injury for his Spanish side that has jeopardized his chances of playing at the upcoming 2026 FIFA World Cup.
Diego Simeone has insisted Atletico Madrid were the better side despite being held to a 1-1 draw by Arsenal in the first leg of their UEFA Champions League semi-final on Wednesday night.
