The visitors began the day in the commanding position of 266/2 in pursuit of 344, but the West Indies fought back to restrict them to just a 43-run lead. However, they floundered with the bat and were just 60 runs ahead with six wickets down at the close of play.
Pakistan captain Barbar Azam (88) added just two to his overnight total before pressure resulted in a hurried single, Brandon King got the direct hit and Azam didn't make his ground.
And the wickets continued to tumble as they lost three more before lunch. Chief destroyer Jomel Warrican clean bowled Awais Zafar and Mohammad Rizwan, while Shamar Joseph trapped Salman Agha in front for a duck
Centurion Abdullah Shafique (160 not out) continued to prod and probe in the chaos around him and finally found a willing partner in Sajid Khan (30). The pair went past the West Indies total and put on a gritty 59 runs together before Jayden Seals got the breakthrough, leaving them 370/7.
Seamer Warrican returned to wrap up the tail in quick time and ended with deserved figures of 6/112.
The West Indies started their second innings well enough, but Tagenarine Chanderpaul (17) fell to spinner Khan with 40 on the board. On a deteriorating pitch, Khan went to work to pick up three more scalps before the close of play, leaving the hosts 103/6, only 60 runs ahead.
Joe Root will return to the captaincy when England begin their three-match Test series against Pakistan later this month, with selectors announcing a 16-man squad for the opening two fixtures.
West Indies Test captain Roston Chase admitted it was a combination of team balance, a spin-friendly pitch and tactics that led to their eight-wicket loss to Pakistan.
Pakistan wrapped up an eight-wicket victory on the fourth day of the second Test against West Indies in Trinidad, to see the tourists walking away with a 1-1 draw in the two-match series.
Pakistan seized control of the second Test by stumps on day two, reaching 266 for 2 in reply to West Indies' 344 to trail by just 78 runs after producing their strongest batting display of the series.
