It's the oldest rivalry in rugby. Scotland claimed the Calcutta Cup and ended England's 12-run win streak with a bonus-point win in front of the Murrayfield faithful.
The stunning result also eased pressure on coach Gregor Townsend, who came under heavy fire following their loss to Italy last week. It marked the first time in eight attempts that Scotland had beaten a top-ten-ranked nation.
As such, there was much riding on the result, and Tuipulotu's men came up trumps with enterprising play and ruthless execution.
"Beyond proud," Tuipulotu told the BBC after the match.
"I'm proud of everyone involved. I see everything that goes on behind closed doors that everyone else doesn't get to see.
"I stand by what I said during the week, and I'm happy we got behind our coach today and put in a performance we can be proud of.
"I want to enjoy tonight with my teammates, but make no mistake, we'll be all hands on deck [next week]."
Scotland travel to Cardiff to face troubled Wales next week.
Meanwhile, opposn captain Maro Itoge admitted he and his England teammates did not play up to their expectations.
"It was a tough day at the office, we didn't get firing in the way we wanted to, but that is the nature of the beast," he said.
"We have to learn our lesson and move forward. We didn't start well, we were not as accurate and precise as we wanted to do be, in the scrum especially, all of those areas need to be better."
Andy Farrell has tweaked his Ireland selection for the Six Nations clash with Wales national rugby union team, rewarding three Ulster players with spots in the starting XV following the statement victory over England.
Wales head coach Steve Tandy has adjusted his starting XV for Friday's Six Nations meeting with Ireland at the Aviva Stadium, including recalls and injury-forced reshuffles.
England head coach Steve Borthwick has made no less than nine changes to his matchday 23 that will face Italy in the Six Nations at the Stadio Olimpico in Rome on Saturday.
Everton manager David Moyes has said Kiernan Dewsbury‑Hall is closer than many think to forcing his way into the England squad if he keeps producing strong performances for the Blues.
