There is one alteration to both the forward pack and backline as Los Pumas look to respond from a Round One defeat in Cordoba that saw them go down to a 41-24 loss.
A scorer last week, Rodrigo Isgro, is missing from the matchday 23 entirely and has been replaced by Mateo Carreras, with Bautista Delguy swapping wings in the move.
The other tweak to Contepomi's XV sees Juan Martin Gonzalez promoted from bench duty in place of Marco Kremer in a straight swap from last week's opening meeting.
That means Gonzalo Garcia and the impressive Tomas Albornoz continue as the half-back combination while Santiago Chocobares and Lucio Cinti are the midfield pairing.
Juan Cruz Mallia continues in the full-back jersey and will look to provide a spark to Los Pumas attack in what is a must-win match for their Rugby Championship hopes.
Up front it's the same front-row of Mayco Vivas and Pedro Delgado either side of hooker and captain Julián Montoya with Franco Molina and Pedro Rubiolo the two locks.
Joining the tireless Gonzalez in the back-row is the hulking Pablo Matera and Joaquín Oviedo, who will pack down on the blindside flank and at number eight, respectively.
Kremer is set to emerge off the bench alongside Ignacio Ruiz, Nahuel Tetaz Chaparro, Joel Sclavi, Guido Petti, Simon Benítez Cruz, Santiago Carreras and Justo Piccardo.
Argentina - 15 Juan Cruz Mallia, 14 Bautista Delguy, 13 Lucio Cinti, 12 Santiago Chocobares, 11 Mateo Carreras, 10 Tomas Albornoz, 9 Gonzalo García, 8 Joaquin Oviedo, 7 Juan Martin Gonzalez, 6 Pablo Matera, 5 Pedro Rubiolo, 4 Franco Molina, 3 Pedro Delgado, 2 Julian Montoya (c), 1 Mayco Vivas.
Replacements: 16 Ignacio Ruiz, 17 Nahuel Tetaz Chaparro, 18 Joel Sclavi, 19 Guido Petti, 20 Marcos Kremer, 21 Simon Benitez Cruz, 22 Santiago Carreras, 23 Justo Piccardo
Springbok captain Jesse Kriel says his team has learned their lessons from last week's defeat to the Wallabies and are determined to set things right when the sides meet again.
All Blacks hooker Codie Taylor honoured those who have come before him as he prepares to earn his 100th cap on Saturday against Argentina.
Aphelele Fassi will start at fullback for the Springboks' Rugby Championship clash with the Wallabies in Cape Town on Saturday, after Willie le Roux was ruled out with a training niggle.
Hooker Codie Taylor will become the 14th All Black to reach 100 Test caps when he runs out against Argentina for the second round of the Rugby Championship.
