Punjab Kings were the latest opposition to inflict a loss on Jayawardene's side with a seven-wicket victory at the Wankhede Stadium on Thursday.
After starting the tournament with a win, Mumbai India have lost all their other matches and sit second from bottom on the IPL table.
Jayawardene said: "It's pretty much on me, everyone who is involved in the management and all that to see how can we be better.
"I know we are playing good cricket. We are not taken out completely, but at the same time the other teams are much better, clinical; obviously the confidence is high as well when they have that kind of start so we just need to control phases that we can control.
"So I think it's not just on one individual. As a franchise, as a team management, we need to do things better to get into some rhythm and then get a few wins under our belt that will give us that confidence."
Mumbai Indians will look to get back on the winning trail when they travel to Ahmedabad to take on Gujarat Titans on Monday.
"I think the four games that we lost - two away and two at home - were different kind of games and we did try some combinations and some of those combinations were forced on us because of injuries and players not (being) available," Jayawardene said.
"So (we are) trying to create something of what is available. But we are finding some spark in certain areas but the other side is finding that especially with the ball; we haven't been able to penetrate oppositions so that's something that we really have to work harder (at) and see how we can improve on that."