Batting at number three, Kishan struck 103 from just 43 balls as the home team went to a mammoth total of 271-5 in their 20 overs.
The left-handed Kishan hit 10 sixes and six fours in his knock and received good support from his captain Suryakumar Yadav (63 off 30), Hardik Pandya (42 off 17) and Abhishek Sharma (30 off 16).
New Zealand's bowlers were put to the sword in the first innings with fast bowler Lockie Ferguson returning the best figures of 2-41 his four overs.
The Black Caps made a good fist of the huge run-chase with opener Finn Allen striking 80 off 38 deliveries while Rachin Ravindra contributed 30.
Ish Sodhi stroked a lusty 33 off 15 balls towards the end of the contest as India seamer Arsheep Singh ended with 5-51 in his four overs.
Both teams will take valuable information and preparations start for the T20 World Cup that kicks off on 7 February.
New Zealand put in a much improved display to beat a India by 50 runs in the fourth T20I in Visakhapatnam but the tourists still find themselves 3-1 down in the series with one game remaining.
Former India head coach Rahul Dravid says the lack of preparation for Test cricket has contributed to the team's recent struggles in the longest format of the game.
India's march through T20 cricket gathered fresh momentum in Guwahati as they crushed New Zealand by eight wickets to seal the series with two games to play, extending a remarkable run that stands at 11 straight T20I series or tournament victories.
India's explosive batting depth was on full display in Raipur as Ishan Kishan and captain Suryakumar Yadav dismantled New Zealand to secure a seven-wicket win in the second T20I and take a 2-0 lead in the five-match series.
