Thomas Tuchel's side travel from their training base in Kansas City knowing they face not only the tournament co-hosts but also the demanding conditions of Mexico City's high altitude. The stadium sits 2,240 metres above sea level, where thinner air makes breathing more difficult and the ball travels faster.
Rashford admits the conditions will make life harder but stresses England's experienced squad are not concerned by the challenge.
"It's going to be tough," Rashford says. "There are no easy games in the World Cup. Different teams bring different problems to us.
"It's up to us on the pitch and on the training ground to find new solutions."
The forward adds: "The altitude obviously plays a factor but it's not something that we're worried about. We're all experienced players. We have to manage the game."
Mexico head into the knockout stage as one of the tournament's most organised teams. Javier Aguirre's side have played every World Cup match at the Azteca, where they boast an outstanding record, losing only twice in 89 matches. They also remain unbeaten in the tournament after keeping four consecutive clean sheets.
Rashford praises Mexico's organisation and believes England must be at their best to book a place in the quarter-finals.
"So far, they've shown they're difficult to score against," he says. "They've been scoring goals, especially early on.
"It's a team that's set in their ways in terms of playing style. They're effective.
"There are lots of great teams in the tournament. If we want to get to the final and win it, we're going to have to come up against them and find a way to do it."
Away from international duty, Rashford's club future remains uncertain after returning to Manchester United following his loan spell at Barcelona. The 28-year-old reveals he hoped to resolve his future before the World Cup began but is now putting those discussions on hold until England's campaign is over.
"Me as a person, I live in the moment," Rashford says. "I was very clear with everyone involved before the World Cup. I wanted it done before but if it's not, then I won't be dealing with it until after because I want to be fully present in this moment and at the same time we're fighting to do something so special."