Third placed Usuthu will be looking to continue their good form prior to the recent FIFA international break where they drew once and won their last two league matches.
Meanwhile, Babina Noko will attempt to end a four match winless streak in the Betway Premiership which has seen them slip to sixth spot on the table.
The two teams have met on nine previous occasions in the Premier Soccer League top division, with three wins for each team and three draws including the first round clash which ended 1-1 in August last year.
However, on a more personal level, the Durban based side's head coach Arthur Zwane is yet to taste victory in a league clash against Sekhukhune's Eric Tinkler, with the latter beating '10111' twice while at the helm of Cape Town City before the draw earlier this season.
A victory for Tinkler's side will see them draw level on points with AmaZulu and usurp them into third spot due to a superior goal difference, while a draw with take them to fifth position.
Both sides have played 22 matches so far this season. Kick-off is at 17h30.
TS Galaxy came back from behind to defeat Milford FC 4-3 on penalties following a 1-1 draw in their Nedbank Cup semi-final at the Solomon Mahlangu Stadium on Sunday afternoon.
Casric Stars are dreaming big this season as they chase both the Nedbank Cup and promotion from the Motsepe Foundation Championship (MFC).
Mamelodi Sundowns coach Miguel Cardoso has urged his team not to get carried away by their nine-game winning streak, stressing there is no room for error in the final stretch of the season.
Jomo Cosmos chairman Jomo Sono has strongly suggested that the majority of coaches in the Betway Premiership don't have full control of their teams.
