The 23-year-old has been sidelined since suffering the injury during pre-season and had recently returned to training. However, after specialist consultation, it was determined that surgery is now required to resolve the issue.
"Following specialist consultation, it has been determined the defender will undergo a surgical procedure to address the issue," Everton said in a statement. "Branthwaite will commence a structured rehabilitation programme under the supervision of the club's medical team following the operation."
The setback delays what would have been Branthwaite's first appearance of the season. The injury was initially considered minor, but complications during recovery led to this more serious intervention.
Branthwaite signed a new deal in July, committing his future to Everton until 2030. Despite not featuring this season, he was a standout performer over the past two campaigns, racking up 65 Premier League appearances and earning senior England recognition.
Chelsea's 18-year-old winger Estevao produced an impressive cameo performance off the bench in a 3-0 Premier League victory over Wolves on Saturday, earning praise from manager Enzo Maresca.
Arsenal saw their winning run ended by Sunderland, while Chelsea claimed a convincing victory over Wolves in Saturday's Premier League action.
David Moyes has voiced his frustration over Thierno Barry's growing pains at Everton, criticising the striker's rash tackling and lack of discipline that have already cost him valuable minutes on the pitch.
Brighton head coach Fabian Hurzeler says his players unanimously believe Danny Welbeck deserves a recall to the England squad, as calls grow for the in-form striker to be included in Thomas Tuchel's selection for this month's World Cup qualifiers.
