Sirino returns to the fold after serving a one-match suspension, having sat out the 2-1 defeat to Al Masry in the group opener due to an accumulation of three yellow cards.
The Glamour Boys will also hope for improved attacking impetus after a blunt showing in Egypt, where their late push fell short.
Their quest for redemption continues at the New Peter Mokaba Stadium in Polokwane on 29 November, with home advantage expected to play a key role in lifting the side's confidence.
Chiefs were further hampered in their opening outing by the absence of Glody Lilepo, who missed the trip through injury. His potential involvement this weekend would offer another welcome boost as coach and players seek a response to their disappointing start.
The challenge ahead, however, is a stern one. Zamalek opened their group campaign with a solid 1-0 victory over Zesco United, underlining their pedigree and signalling their intent to seize early control of the pool.
Chiefs will therefore need to be sharp, disciplined, and clinical if they are to claim their first points of the competition and reassert themselves in the race for knockout qualification.
Kaizer Chiefs co-coach Khalil Ben Youssef has urged calm and perspective after his side opened their CAF Confederation Cup Group D campaign with a 2–1 defeat to Al Masry.
Kaizer Chiefs co-coach Khalil Ben Youssef insists the club have not lowered their expectations, as they aim for silverware this season.
Kaizer Chiefs conceded in the dying moments of a demoralising defeat to Egyptian side Al Masry, while Stellenbosch scored in the last-minute to beat Congolese side AS Otoho D'Oyo in CAF Confederation Cup opening-round action on Sunday night.
Stellenbosch FC head coach Steve Barker says his side is fully prepared for a challenging opening clash of the CAF Confederation Cup Group Stage when they host Congolese outfit AS Otoho at the New Peter Mokaba Stadium on Sunday.
