The Inter Miami captain caused concern when he asked to be substituted during his side's dramatic 6-4 win over Philadelphia Union on Sunday.
Messi appeared uncomfortable as he walked off with around 20 minutes remaining and was seen touching the back of his thigh before heading to the bench.
For many Argentina supporters, it was an anxious moment. Messi had little reason to leave such an important match unless there was a genuine issue, especially with Inter Miami locked in a thrilling 4-4 contest at the time.
Inter Miami eventually secured victory thanks to late goals from Luis Suarez and Rodrigo de Paul, but the main talking point after the match remained Messi's condition.
The first reports from Argentina have since offered reassurance. Journalist Gaston Edul revealed that Messi requested the substitution purely as a precaution after feeling tightness in his hamstring. Initial checks reportedly showed no muscle injury, with the veteran forward deciding not to take any unnecessary risks.
At 38, Messi and Argentina's medical staff are expected to carefully manage his fitness as preparations continue for the World Cup. Any sign of discomfort involving the eight-time Ballon d'Or winner is always likely to spark concern, particularly given his importance to both club and country.
The latest update, however, suggests Argentina avoided a major scare. Messi's decision to come off early now appears to have been a sensible precaution rather than the start of another injury setback.
Argentina fans will now hope their captain returns to full training quickly as attention turns towards the build-up to the World Cup.
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