The two teams are set to do battle at the Loftus Versfeld on Friday evening with the return leg set to be played in Bamako on Sunday, March 22.
Masandawana will be looking to progress to their third consecutive final of the continental competition, after being runners-up last year to Pyramids FC.
The Chloorkop side are coming up against the surprise package of the tournament so far, with Malien topping Group D ahead of the more fancied African giants Esperance de Tunis.
"We need to approach this [CAF] Champions League round with Stade Malien in between until the [FIFA] break with all the players available, so that we can have the highest power," said Sundowns head coach Miguel Cardoso ahead of the match.
"We knew that we wanted to spare players [against Orbit College], especially the ones in the front that can give a lot, like Arthur [Sales], Nuno [Santos], Tashreeq [Matthews], Iqraam [Rayners], Brayan [Leon], and Saleng. But we could not spare all of them."
Stade Malien are making their first appearance at the group stage and knockout stage of the CAF Champions League and are looking to continue rewriting history by winning the title on the first attempt.
Mamelodi Sundowns coach Miguel Cardoso is expecting a competitive and physical encounter against Stade Malien in the first leg of their CAF Champions League quarter-final.
Stade Malien head coach Mauril Njoya says his side are capable of springing a surprise by beating Mamelodi Sundowns in their upcoming CAF Champions League quarter-final.
Kaizer Chiefs have issued a strong response following the protest staged by a group of supporters outside the club's headquarters in Naturena on Saturday, stressing that while fan passion is valued, threats and disorder will not be tolerated.
Kaizer Chiefs sporting director Kaizer Motaung Jr. has defended the club's decision to entrust assistant coaches Khalil Ben Youssef and Cedric Kaze with leading the team following the departure of former head coach Nasreddine Nabi.
