The Brazilians are clear favourites heading into the tie based on their previous experience in the continental competition.
Cardoso's team are expected to progress to the semi-finals but Stade Malien have already proved their worth in this season's competition by ending as Group D winners, ahead of ES Tunis, Petro de Luanda and Simba SC, while Sundowns qualified for the knockout stage as runners-up of Group C.
Ahead of the game, Cardoso said on iDiski Times: "It's a team that has a lot of physicality, in some moments, some teams suffered a lot with that in the group stages.
"But also, that physicality can play against you because also sometimes there are more attractions on the ball, let's see.
"But Sundowns players have experience also and if they take it to the limit and understand how to approach the game tactically and strategically, probably it can work."