The latest setbacks came during their Champions League clash against Real Madrid, where enforced substitutions weakened their performance.
Pep Guardiola was finally able to field his preferred XI - except for Rodri - for 30 minutes, but the plan was disrupted when Jack Grealish suffered an injury.
This led to a tactical reshuffle, with Phil Foden moving to the right. Manu Akanji also went off injured, forcing Rico Lewis into the game, who was then targeted by Madrid.
Nathan Ake, making his return, managed 60 minutes but was forced off, with his final action inadvertently playing Kylian Mbappe onside for the equaliser.
City's season-long injury struggles have seen players staying on the pitch despite not being fully fit, while frequent changes to the defensive line have disrupted their rhythm. Guardiola now faces a selection dilemma ahead of a crucial period.
The Premier League clash against Newcastle is followed by the second leg against Real Madrid next week.
Guardiola must carefully balance squad selection, particularly given the fitness concerns surrounding Ake, Akanji, Grealish, Jeremy Doku, and Nico Gonzalez.
Past squad rotations have backfired-Gonzalez was injured early against Leyton Orient and missed the Madrid tie.
Eddie Howe marked his fourth anniversary as Newcastle manager with another away defeat, a 3–1 loss to Brentford that stretched their winless Premier League run on the road to nine games.
Pep Guardiola celebrated his 1000th match as a manager in fitting fashion on Sunday, guiding Manchester City to a commanding 3-0 win over Liverpool at a rain-soaked Etihad Stadium.
Arne Slot admitted that his tactics were to blame for Liverpool's 3-0 defeat to Manchester City, as Pep Guardiola marked his 1,000th game with a dominant display at the Etihad Stadium.
Manchester City cruised to a commanding 3–0 victory over Premier League title rivals Liverpool at the Etihad Stadium on Sunday evening.
