The Buccaneers have ended as runners-up to the Brazilians for the past three league seasons but have a real chance to claim championship honours this term.
Heading into Wednesday's encounter at the FNB Stadium, Ouaddou's charges top the standings with 38 points from 16 games, while Miguel Cardoso's team are in second with 32 points from 15 matches.
Bucs most recently overcame Tshakhuma Tsha Madzivhandila in a Nedbank Cup last 32 clash but Ouaddou explained that he has paid more attention to their upcoming league clash.
"It was a while since we've been preparing for this game, let's say two weeks ago, we already started having the games in our mind. Even though we were focused on the Nedbank Cup and the Gallants match as well, explained the Bucs boss on Soccer Laduma.
"We've prepared well, mentally, physically of course. We played a few days ago so now it's only regeneration for our side and we will go deeper in terms of tactical."
Sundowns come into this game after beating MC Alger to secure their place in the knockout rounds of the CAF Champions League.
"My players are ready, there's a lot of trust, confidence and unity as well," added Ouaddou. "Something that speaks to us, something that has been with us since the beginning of the season.
"You know that it's one of the biggest Clasico's in Africa," he said. “We are not talking about this kind of game only in South Africa, we are talking about a game for the whole continent.”