Following Monday's draw, conducted after the completion of the round of 16 fixtures, the outstanding details regarding venues and kick-off times have now been finalised - setting the stage for an exciting last-eight lineup.
AmaZulu FC, who last reached the final in 2010, will host giant-killers Casric Stars at the Moses Mabhida Stadium on 7 March at 15:00. Stars booked their spot in dramatic fashion after eliminating Orlando Pirates on penalties at the Orlando Amstel Arena in the previous round.
Later that evening, Sekhukhune United - runners-up in the 2022/23 season - will take on Motsepe Foundation Championship leaders Milford FC at the Peter Mokaba Stadium, with kick-off scheduled for 18:00.
The action continues on Sunday as TS Galaxy face ABC Motsepe League side JDR Stars at the Solomon Mahlangu Stadium at 15:00. Galaxy, who famously lifted the trophy in the 2018/19 season, also stunned Mamelodi Sundowns in the round of 16.
The final quarter-final fixture will see Golden Arrows host Durban City FC in a Durban derby at the King Zwelithini Stadium on Sunday at 18:00.
The winner of the Ke Yona Cup will earn the right to represent South Africa in next season's CAF Confederation Cup.
Another Friday night lights action in the Betway Premiership brings two exciting fixtures, which will see a Limpopo derby, while the battle of the provinces will feature Cape Town taking on KwaZulu-Natal.
AmaZulu head coach Arthur Zwane is confident his young side will be able to fulfil its target of claiming a top four finish in the 2025/26 Betway Premiership.
We take a look at five key factors ahead of Saturday's Betway Premiership derby between Kaizer Chiefs and Orlando Pirates at FNB Stadium.
Defending champions Mamelodi Sundowns reclaimed top spot in the Betway Premiership with a dramatic 1-0 victory over AmaZulu at Moses Mabhida Stadium on Tuesday night, settled by a late Marcelo Allende strike.
