Isak, 25, is under contract at St James' Park until June 2028, having signed a six-year deal in 2022 when he joined from Real Sociedad for 63 million pounds.
However, amid growing transfer interest, particularly from Liverpool and clubs in Saudi Arabia, the Sweden international's long-term future is no longer certain.
Newcastle manager Eddie Howe and the club's ownership remain determined not to lose the in-demand forward this summer. But with Liverpool having approached the Magpies to indicate a willingness to make a big-money bid should Newcastle's stance soften, pressure is mounting.
Isak's omission from the squad for the recent friendly defeat to Celtic has only intensified speculation. The forward was sent home by Howe as off-pitch uncertainty continues to swirl.
A failure to resolve Isak's contract situation could leave Newcastle facing an even tougher dilemma next summer.
If no new deal is agreed and the player isn't sold, the club may risk his value declining or a possible future exit on less favourable terms.