South Africa will kick off their campaign against El Tri on June 11 in a fixture that rekindles memories of the 2010 World Cup opener, when the two nations played out a 1-1 draw in Johannesburg.
With Mexico enjoying home support and carrying a wealth of World Cup experience, Williams expects a stern test for Hugo Broos' side but believes the occasion is one the squad is relishing.
"Yeah, I mean, they are an amazing team," Williams told Sporty TV.
"They are highly experienced and have been part of the World Cups before. They've got the experience; they've got the players.
"And the most important thing, they've got the supporters, fans, and the home ground advantage. And that is always key, so we're excited; we will obviously analyse them. We will watch the games, and I think it's gonna be a good game; we're excited."
While the challenge posed by Mexico is clear, the prospect of playing at the legendary Estadio Azteca has added another layer of excitement for the Bafana skipper.
Widely regarded as one of football's most historic venues, the stadium has hosted some of the sport's most memorable moments and will stage the tournament opener as Mexico begin their role as co-hosts alongside the United States and Canada.
"That's historic, it's what it stands for in football," Williams said.
"Words can't describe how important that stadium is, and what it means not just to Mexico but the entire world; it's amazing, I can't wait to feel the atmosphere."
For Williams, who recently lifted the CAF Champions League with Mamelodi Sundowns, leading his country at a World Cup represents the pinnacle of his career.
"This is probably the cherry on the top of a wonderful career I've had," he said.
"I don't think there's anything that will top this."
South Africa head into the tournament looking to make history of their own. Bafana have featured at three previous World Cups but have never progressed beyond the group stage, with Broos targeting a breakthrough appearance in the knockout rounds.
Although recent form has been inconsistent, with just one victory in their last six matches across all competitions, the underdog label could suit a South African side determined to upset the odds in a group that promises to be fiercely competitive.
A positive result against Mexico would not only mark a dream start to their campaign but also provide a symbolic response to the disappointment of 2010, when a draw against the same opponents was ultimately not enough to help the hosts advance.
Bafana Bafana legend Sibusiso Zuma has questioned how several players were told they would not make South Africa's 2026 FIFA World Cup squad, saying head coach Hugo Broos could have handled it better.
Mbekezeli Mbokazi's impressive rise in Major League Soccer has reached another milestone after the Bafana Bafana defender earned selection to the 2026 MLS All-Star Team, placing him alongside some of the biggest names in world football.
Mohau Nkota's difficult season in Saudi Arabia has suffered another major setback after Al Ettifaq confirmed the South African winger has undergone knee surgery, ruling him out for an extended period.
Mexico have delivered a warning to their opening World Cup opponents Bafana Bafana with a commanding 5-1 victory over Serbia in their final warm-up match in Toluca on Thursday night.
