The two sides meet for the second time in a week, with Sundowns having comfortably beaten the Chilli Boys 3-0 in their previous encounter.
Masandawana sit 15 points clear at the summit of the Betway Premiership, chasing a record-extending eighth consecutive title.
Under the guidance of head coach Miguel Cardoso, Sundowns have found imperious form, winning their last four league matches and netting 11 goals in the process.
Their most recent outing was a commanding 3-0 win over Stellenbosch at the weekend.
"Obviously, be honest in the way we play the next two matches and it's a big responsibility that we have ahead," said Cardoso.
"Regarding more than that, I would like to leave it for the moment that we really become champions, because at the moment there's no time for that.
"We need to really focus ourselves in what we have to do..."
Goalkeeper Ronwen Williams is expected to be available again, offering a further boost to an already dominant side.
Their last defeat came at the hands of title challengers Orlando Pirates, but since then, Sundowns have looked unstoppable.
In stark contrast, Chippa United are enduring a worrying slump, having failed to win any of their last five league fixtures.
Still clinging to eighth place - the final MTN8 qualification spot - they are level on points with Kaizer Chiefs and Marumo Gallants, separated only by their -3 goal difference.
Coach Thabo September's squad remains depleted in midfield. Siphelo Baloni has been out since sustaining an injury against Richards Bay in March, while Andile Jali has not featured since February.
Speaking after their 3-0 defeat to Stellenbosch on 30 April, September provided little optimism regarding their return.
Stellenbosch FC head coach Steve Barker believes Iqraam Rayners deserves serious consideration for the DStv Premiership Player of the Season award, naming the Mamelodi Sundowns forward among the standout performers of the 2024/25 campaign.
Kaizer Chiefs midfielder Gaston Sirino has thrown his weight behind a former Mamelodi Sundowns teammate as the standout performer of the 2024/25 season, naming him as his pick for the PSL Footballer of the Season.
Mamelodi Sundowns head coach Miguel Cardoso has expressed his frustration over what he feels is a lack of appreciation for his efforts at the club since his arrival in December.
We take a closer look at former Bafana Bafana star Bongani Zungu's life and career, the man who has also played for numerous teams in Europe.
