The 32-year-old Wales international was stretchered off after receiving oxygen, and the injury now casts doubt over his participation in Wales' upcoming World Cup play-off semi-final against Bosnia and Herzegovina on 26 March.
Spurs issued a statement on Monday, saying: "We can confirm that Ben Davies will undergo surgery today for a fracture of his left ankle. Following the surgery, Ben will commence his rehabilitation with our medical staff. We're all behind you, Ben."
Davies, who captained Wales in Aaron Ramsey's absence and earned his 100th international cap against Belgium in October, faces a potentially lengthy lay-off. His absence is a significant blow to Wales ahead of their home semi-final, with the winner set to face Northern Ireland or Italy in the March final.
For Tottenham, the setback compounds a difficult period. The defeat to West Ham left Spurs 14th in the Premier League, having won just two of their 11 home games this season. The result continued a poor run of form, with no wins in their last four league matches. Fans vented their frustration at the full-time whistle, chanting against manager Thomas Frank, who was appointed in June following Ange Postecoglou's departure.
Frank acknowledged the supporters' anger but defended his players' effort: "It's not a nice feeling, but I understand the frustration. We are losing to a big London rival, there is nothing worse. We couldn't win at home, which we worked very hard to try to do that. Hopefully they can see the effort from the boys, they are working very hard."
The match highlighted issues in Spurs' defensive game, particularly in set-piece situations, which Frank admitted need improvement. Despite the mounting pressure, the board has maintained their support for the former Brentford boss.
Tottenham now face a congested schedule, with Champions League action against Borussia Dortmund looming, while simultaneously managing an injury-hit squad. For Davies, the focus will be on recovery and getting back to full fitness for both club and country.
Paul Scholes has clarified that his recent social media comment about Manchester United head coach Michael Carrick was not intended as criticism and said he contacted his former team-mate directly to explain the remark.
Chelsea head coach Liam Rosenior defended his decision to heavily rotate his squad after his side needed extra time to beat Wrexham 4-2 and reach the FA Cup quarter-finals.
West Ham manager Nuno Espirito Santo has urged refereeing chiefs to visit clubs and clarify what constitutes a foul at set-pieces, warning that current levels of grappling and blocking are "almost crazy".
Nottingham Forest's global head of football Edu Gaspar has been told to stay away from the club's stadium and training ground as uncertainty grows over his future.
